Easier access to the marrow space
from an anterior or posterior position with reduced risk of unintended surgical trauma because the flexible needle will not penetrate cortical bone.
Classical radiological signs of Paget's disease include osteoporosis circumscripta, blade of grass presentation, flame shaped lesions, cotton wool appearance, osteosclerosis, periosteal new bone formation, increased thickness and circumference of bone, trabecular disorganization, compression from softening of bone, separation and displacement of teeth, hypercementosis, thickening of the iliopubic and ilioischial lines, ivory vertebrae, picture-frame vertebrae, enlarged cranium with increase in the marrow space
, and intense uptake of radioactive tracers by involved bone.
The transplanted bone marrow cells migrate to the marrow space
and actually begin the process of repopulation.
Design features ensure easy identification of the site, quick and accurate penetration to the correct depth in the bone marrow space
, resistance to strain and external forces, and immunity to interference with other procedures.
As shown in Figure 4, PMMA filled the marrow space
in the expected trabecular pattern.
On microscopy, the bone marrow trephine biopsy specimen had a cellularity of 98% (fat cell ratio, 2:98), and the marrow space
was almost completely effaced by an infiltrate of myeloid and monocytic cells, which immunohistochemically were positive for myeloperoxidase.