As a consequence, simvastatin and lovastatin
are widely considered contraindicated in HIV-positive patients.
The effects were similar to those of commonly used statin drugs, even though red yeast rice contains substantially lower amounts of lovastatin
and other monacolins than the dosages of most statin drugs used to treat hypercholesterolemia.
Some recent research suggests that low-to-moderate consumption of grapefruit may be safe for lovastatin
This natural occurring lovastatin
is quite different than a synthetic statin.
s Pravachol is the statin with the highest rate of posts discussing concerns, while lovastatin
has the lowest rate.
A subanalysis that compared moderateand high-dose statin therapy with low-dose therapy (atorvastatin <20 mg, rosuvastatin <10 mg, simvastatin <80 mg, or any dose of fluvastatin, lovastatin
, or pravastatin) found a 22% increased risk of diabetes (HR=1.
Labels on red yeast rice products generally do not disclose their lovastatin
content due to concern that the supplement will be considered an unapproved drug by FDA and removed from the market, since lovastatin
is a prescription drug (originally sold as Mevacor).
For risk group 1, the average dose of lovastatin
was higher in the controlled patients than in the uncontrolled (74 vs.
The researchers found that adding a drug called lovastatin
to traditional antimalarial therapy prevented cognitive dysfunction in mice infected with cerebral malaria.
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin
(Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth af Aspergillus terreus, their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin
Achieving these lower levels almost always requires a statin, including the more potent atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor), and lower-potency fluvastatin (Lescol), lovastatin
(Mevacor) and Pravastatin (Pravachol).
Our aim was to investigate the possible and direct favorable effects of lovastatin
on lef t ventricular (LV) systolic, diastolic function and myocardial ischemia in patients with CAD.
Red yeast rice contains compounds called monacolins; one, in particular, is mevinolin (or lovastatin
,) the same substance found in Mevacor[R], a statin drug produced by Merck & Co.
The HMG-CoA reductase inhibitor lovastatin
impairs IR-stimulated E-selectin expression as analyzed at the level of the protein, mRNA and promoter.