Cancer anorexia-cachexia syndrome (CACS), characterized by decreased body weight, mainly lean body mass
(LBM), is a common, poorly-understood and debilitating condition in patients with cancer, that frequently occurs in patients with advanced NSCLC, for which existing treatment approaches are limited.
The ROMANA data clearly demonstrates that anamorelin increased lean body mass
and improved symptoms related to anorexia and cachexia.
The primary endpoint of the study was lean body mass
measured by dual energy X-ray absorptiometry (DEXA) scan.
The second 12 months were aimed at evaluating the safety of CLA and assessing its effects on body composition (body fat mass, lean body mass
, bone mineral mass, body weight and BMI) over a prolonged period of time.
Lean Body Mass
, a gauge for monitoring pounds of muscle, is displayed once the body fat % is calculated.
In this preclinical mouse model, treatment with dexamethasone resulted in weight loss and a 5% reduction in lean body mass
These data provide evidence for the efficacy and safety of a chitosan compound to facilitate the depletion of excess body fat with minimal loss of fat-free or lean body mass
," the scientists concluded.
Furthermore, it confirmed that taking CLA decreases body fat mass (BFM) and maintains lean body mass
(LBM), and so also aids weight management, reducing the potential "yo-yo" effect often associated with diet plans.
The scientists found the mice resisted diet-induced weight gain and experienced no decrease in lean body mass
The endpoints in the first phase included changes in body composition (body fat, lean body mass
, lean body mass
/fat mass ratio), changes in hyperphagia, changes in behavior, and safety.
Sabinsa Corporation, Piscataway, NJ, has been granted a patent by the European Patent Office for the use of forskolin, the active compound in the company's ForsLean brand Coleus forskohlii extract, as a dietary supplement for the purpose of promoting lean body mass
, shifting the proportion of mass in favor of lean body mass
, reducing fat tissue and encouraging weight loss.
The researchers found that growth hormone had a modest effect on body composition, increasing lean body mass
, or muscle, by slightly more than 2 kilograms and decreasing body fat by roughly the same amount.
ForsLean is a proprietary extract derived from Coleus forskohlii roots--the only known plant source of forskolin, a natural compound that increases lean body mass
and optimizes body composition, according to Sabinsa.
These patents cover methods of administering chromium picolinate to reduce hyperglycemia and stabilize serum glucose, increase lean body mass
and reduce body fat, and prevent undesirable high levels of blood serum lipids.
Patent #5,804,596, method of preparing a forskolin composition for use in promoting lean body mass
and treating mood disorders.