kinetochore


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Related to kinetochore: centrosome
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  • noun

Synonyms for kinetochore

a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

References in periodicals archive ?
Essential roles of Drosophila inner centromere protein (Incenp) and Aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
de Mey, "Taxol induces the assembly of free microtubules in living cells and blocks the organizing capcity of the centrosomes and kinetochores," Proceedings of the National Academy of Sciences of the United States of America, vol.
During the prophase of meiosis I, the synapsed chromosomes form a bivalent structure that also has one exposed minus-face kinetochore and one exposed plus-face kinetochore.
These studies allowed us to gain deep knowledge on such important problems as: attachment of kinetochores to the spindle, kinetochore orientation and re-orientation during prometaphase I and metaphase I, in vivo orientation and segregation of the X chromosome, autosomal univalents, multiple chromosomal configurations (e.
Loss of genomic integrity has been attributed to hypomethylation of repetitive elements, which can lead to inappropriate recombination resulting in defects in cell cycle monitoring check point genes as well as genes involved chromosome condensation, kinetochore structure and function, and centrosome and kinetochore formation (22).
The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
This control can be disrupted by interfering with DNA repair, kinetochore assembly, checkpoints, centrosome duplication, microtubule dynamics and numerous other cellular maintenance processes (42).
Holocentric chromosomes exhibit kinetochore along the major part of their length.
The kinetochore is the part of the centromere to which spindle fibers attach during cell division.
1984) reported that the chromosomes of common buckwheat are similar to each other in size and all have a median kinetochore (m).
When metaphase-arrested oocytes of Chaetopterus were exposed to colchicine, the spindle birefringence gradually disappeared as the fibrils depolymerized (the kinetochore fibers were the longest to persist), but the depolymerizing filaments actually led the chromosomes and inner spindle pole to the cell surface, where the outer meiotic spindle pole was attached.
The CENP-A deposition machinery is recruited to centromeres in a cell cycle-regulated manner by inner kinetochore proteins associated with CENP-A, most notably CENP-C.
The inner kinetochore directly binds to the centromeric chromatin during the whole cell cycle.
As kinetochore fibers form among interacting sets of microtubules of the QMS, astral microtubules radiating from the poles gradually disappear (Fig.