analysis revealed no significant increase in the kinetochore
-positive MN compared with unexposed control cells (data not shown).
are crucial for accurate chromosome segregation because they link chromosomes to spindle microtubules.
The ultrastructure of the diffuse kinetochore
in Luzula nivea.
During the prophase of meiosis I, the synapsed chromosomes form a bivalent structure that also has one exposed minus-face kinetochore
and one exposed plus-face kinetochore
There are a number of mechanisms that can give rise to numerical CIN, including centrosome amplification, spindle assembly checkpoint bypass, malfunctions in sister chromatid cohesion and abnormalities in kinetochore
structure or function (42).
Holocentric chromosomes of arachnids: presence of kinetochore
plates during meiotic divisions.
is the part of the centromere to which spindle fibers attach during cell division.
HZwint-1, a novel human kinetochore
component that interacts with HZW10.
Objective: Accurate chromosome segregation in eukaryotes requires the assembly of the macromolecular kinetochore
complex at centromeres to attach chromosomes to the mitotic spindle.
The inner kinetochore
directly binds to the centromeric chromatin during the whole cell cycle.
fibers form among interacting sets of microtubules of the QMS, astral microtubules radiating from the poles gradually disappear (Fig.
analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
Of interest, in yeast Saccharomyces cerevisiae the spores that are the meiotic products of the sporulation of diploid cells display a lineage-specific asymmetric division of kinetochore
gamma]-Tubulin is more concentrated in the poles where it forms a distinct cap and extends along the distal kinetochore
fibers especially those at the perimeter of the spindle (Fig.
Micronuclei were scored as centromere negative (clastogenic) or centromere positive (aneugenic) based on the presence of CREST staining, which recognizes centromere proteins within the kinetochore
of each chromosome, within each micro-nucleus.