kinase


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  • noun

Words related to kinase

an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

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References in periodicals archive ?
The approach has proven beneficial for researchers who are currently testing broad-spectrum profiling of specific kinase inhibitors in live cells for a more realistic estimate of inhibitor selectivity under more physiological conditions.
The 3D structure for PIM-3 was not available yet, so, the 3D structure of PIM-3 kinase was predicted by homology modeling.
Nexus BioPharma, a preclinical stage biotechnology company, has signed a contract to license TransChem's transition state chemistry technology for kinase inhibition, it is reported today.
Significant changes have been made in cancer treatment from last decade and kinase inhibitors therapy signifies to a latest generation of anticancer treatment that are intended to interfere with a particular molecular target, normally a protein with an important role in tumor development or growth.
Of potential clinical significance, treating mice xenografted to bear a human KRAS mutant colorectal cancer cell line with a combination of a receptor tyrosine kinase inhibitor and a MEK inhibitor induced tumor regression.
Carver College of Medicine, said: "CaM kinase helps regulate calcium, which is essential to heart function, but CaM kinase's calcium connection also can play a role in electrical problems that lead to irregular heart beats and cell death.
Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase.
Changes in intracellular kinase activity were examined by Western Blotting by use of antibodies specific to total and phosphorylated kinase forms.
Polo-like kinase-1 (PLK1) was identified as the principal protein kinase that carried out B23 phosphorylation at this site, and these findings point to PLK1 as a very promising cancer drug target.
More specifically, this diverse collection of major diseases appears to share p38 mitogen-activated protein (MAP) kinase as a stimulatory modulator of three critical pathways involved in the inflammatory process.
This invention provides a fusion protein comprising a PAK4 serine/threonine kinase or a fragment thereof and a second peptide.
EphB4 is a receptor tyrosine kinase that is expressed on epithelial cells during fetal life.
Our studies demonstrate HIV-1 gp120 elicits several different types of signals in macrophages through CXCR4 and CCR5, including calcium elevations, ionic channel activation, non-receptor protein tyrosine kinase activation, and activation of MAP kinases.
This mutation encodes an enzyme, Bcr-Abl tyrosine kinase, that causes white blood cells to proliferate.
DiscoveRx announced today the release of the most detailed comprehensive assessment of interaction profiles of known kinase inhibitors across the kinome published to date in the November 2011 issue of Nature Biotechnology, titled"Comprehensive analysis of kinase inhibitor selectivity.