Current drug treatment options in neonatal hyperbilirubinaemia and the prevention of kernicterus
is a pathologist's term describing the yellow deposits and brain cell death from extremely high levels of bilirubin, generally >25-30 mg/dl.
The serum bilirubin can then be plotted on the nomogram to give the risk for development of kernicterus
and to derive clear recommendations as to whether the infant is a candidate for phototherapy or exchange transfusion.
Enthusiasm was tempered in the US by a perceived difficulty in performing the assay and by confusion regarding the poor correlation between Bf and outcome in premature babies who died with kernicterus
at very low total bilirubin (Bt) concentrations (5).
is also infrequent but has a significant mortality (~10%) and incurable long-term morbidity (~70%).
Because of fears of kernicterus
, careful screening and aggressive management are now the orders of the day.
Jaundiced breastfed term infants have no significant difference in length of phototherapy, and no increased rate of exchange transfusion or kernicterus
compared with jaundiced bottle-fed term infants (SOR: B, based on a low-quality randomized controlled trial and a prospective cohort study).
org 1,2,4,6 ATTENUATED ADENOMATOUS POLYPOSIS COLI See: Hereditary Colon Cancer AUDITORY NEUROPATHY See: Kernicterus
AURICULO-OCULO-VERTEBRAL SYNDROME See: Goldenhar Syndrome AUTISM See also: Autism and Sensory Impairments; Purine Metabolic Disorders; Mental Retardation; Asperger Syndrome; PDD Fetal Alcohol Syndrome/Effect; Heart Disorders Asperger Syndrome Coalition of the United States PO Box 351268 Jacksonville, FL 32235-1268 (904) 745-6741 (866) 4-ASPRGR (427-7747) * info@asc-us.
The national alerts called for hospitals to increase awareness among their medical staff concerning the reemergence of kernicterus
to protect at-risk infants, yet Verdugo Hills Hospital management failed to take any steps whatsoever to response and had no procedures or policies to protect Aidan.
1] In some cases, however, very high bilirubin levels in blood can cause Bilirubin-Induced Neurological Damage (BIND) with long-term neurological sequelae known as kernicterus
In rare instances, the Total Serum Bilirubin (TSB) reaches levels that can cause kernicterus
, a condition characterized by bilirubin staining of neurons and neuronal necrosis involving primarily the basal ganglia of the brain and manifested in athetoid cerebral palsy, hearing loss, dental dysplasia, and paralysis of upward gaze.
f] can rise to concentrations that are neurotoxic, however, resulting in deficits ranging from reversible hearing defects to the more severe and possibly fatal neurological sequelae of kernicterus
Testing and monitoring of bilirubin is used to identify infants at risk for severe hyperbilirubinemia and to help initiate treatment and prevent complications, such as kernicterus
Many pediatricians and family physicians may have never seen a case of kernicterus
, so they may believe it's no longer a possibility.
, the rare neurologic condition that can result from extremely high bilirubin levels, is not an appropriate end point.