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Digestion of the chromatin results in a cell with no nucleus which is known as Karyolysis (KL) (Fig.
d) Photomicrograph of a section of liver (H & E; x100) from a mouse treated with acetaminophen shows extensive centrilobular necrosis, hydropic degeneration of hepatocytes, destruction of central vein endothelium, karyolysis, pyknosis, and karyorrhexis of nuclei.
23: Karyolysis nucleus, blood Sinusoid and sulpaing in the central vein.
On examination of the Hematoxylin and Eosin stained sections of the diabetic group, it revealed myocardial disarray accompanied with loss of the normal striated architecture of the cardiomyocytes with presence of characteristic degenerative changes of the nuclei in the form of pyknosis, karyorrhexis, and karyolysis.
In treated rats with platinum azidothymidine, there were many regions with karyolysis and pyknosis that were signs of apoptosis and also some regions showed necrosis.
Nucleolar damage of photoreceptors that occurred after exposure include an early stage of nucleolar condensation (Figure 6B), karyolysis (Figure 6C), pyknosis (Figure 6D-E), and karyorrhexis (Figure 6F).
Kidney: Microscopic lesions in kidneys of rabbits (group A3) hemorrhages moderate tubular cell swelling epithelial necrosis karyolysis cystic dilated tubules and some of cells have vaculation of cytoplasm were seen.
Necrosis was characterized by pyknosis, karyorhexis and karyolysis of nuclei in tubular epithelial cells.
Similarly, necrotic cell death has been reported accompanied by irreversible changes in the nucleus, such as karyolysis, pyknosis and karyorrhexis (21) as well as the loss of structure and fragmentation of the cytoplasm, similar to what is observed at high magnification (Figure 2A3c) when compared with the nonischemic control (Figure 2A1a).
Treatment with Cd caused severe liver damage including fatty changes, focal necrosis, pyknotic nuclei, karyolysis, proliferation of kupffer cells and bile ductless (Figures 1c,1d,1f).
Ishikawa et al (34) based their morphologic assessment of viability on the description in the 2nd edition of Robbins and Cotran Pathologic Basis of Disease, which is similar to the description in the 7th edition: Necrotic (irreversibly injured) cells show increased eosinophilia (acidophilic cytoplasm) and 1 of 3 patterns of nuclear changes--pyknosis, karyorrhexis, or karyolysis.
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