Of the three patients who we successfully treated, two were given itraconazole
and one received fluconazole after an initial course of amphotericin B.
In stable patients such as the patient in our case, itraconazole
treatment for 6 to 18 months may be the initial choice.
Treatment with liposomal amphotericin B was started but switched to itraconazole
after 1 month.
According to a recent report from the Anticancer Fund in Belgium (affiliated with Reliable Cancer Therapies), "Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole
, and there are additional reports of activity in leukemia, ovarian, breast, and pancreatic cancers" (Pantziarka 2015).
After an uneventful recovery, treatment with itraconazole
(10 mg/kg PO q12h, 30 days, Sporanox, Janssen Pharmaceuticals USA, Titusville, NJ, USA) and amphotericin B nebulization (1 mg/mF of saline for 15 minutes q8h for 2 days) was added to the treatment regime.
All isolates were screened by using 2 methods: antifungal plate culture and itraconazole
Etest (bioMerieux, Marcy l'Etoile, France).
Systemic Theropy Fingernails Fluconazole (3) * 3 to 8 mg/kg pulsed-dose weekly for 6 weeks OR 200 mg/week for 8 to 16 weeks Itraconazole
(4) 400 mg/day for 1 week/month, repeated for 2 or 3 months (dagger) Terbinafine (7) 250 mg/day for 6 weeks Toenails Fluconazole (3) 200 mg/week for 12 to 24 weeks Itraconazole
(5) 400 mg/day for 1 week/month, repeated for 3 or 4 months (double dagger) Terbinafine (7) 250 mg/day for 12 weeks * Although it is commonly used for onychomycosis, this is not an FDA-approved indication for fluconazole.
was administered intravenously to dogs and healthy human volunteers, negative inotropic effects were seen.
The patient was treated successfully with oral itraconazole
for 6 weeks.
Food and Drug Administration for its Abbreviated New Drug Application for Itraconazole
Capsules, 100 mg.
After initial treatment with amphotericin B, she was given oral itraconazole
for lifelong suppressive therapy.
Cross resistance to itraconazole
(Sporanox) was present in five women and to ketoconazole (Nizoral) in four
It was combined in turn with four poorly water soluble drugs of different properties and biomedical functions: carvedilol (a nonselective adrenergic receptor blocker, indicated in the treatment of mild-to-moderate congestive heart failure), itraconazole
(an antifungal agent that impairs ergosterol synthesis, used among others against histoplasmosis, cryptococcal meningitis, and aspergillosis), nevirapine (a potent, non-nucleoside reverse transcriptase inhibitor used for treatment of HIV infection and AIDS), and nimodipine (a calcium channel blockader with preferential cerebrovascular activity).
6, 7) In an in vitro study, it was observed that itraconazole
dissolved Viscogel within three minutes of hand mixing and it is not possible to incorporate more than 5% wt/wt itraconazole
into tissue conditioners.
He said that Itraconazole
(brand name Sporanox) and Fluconazole (brand name Flucan or Diflucan) are safer alternatives to treat fungal infection over a longer time without having side effects on the liver.