and phenelzine are the 2 hydrazine MAOIs available in the United States, while tranylcypromine and selegiline transdermal are nonhydrazines (Figure 2).
is approved for the treatment of depression.
Phenelzine (Nardil[R]), tranylcypromine (Parnate[R]), isocarboxazid
(Marplan[R]), and selegiline (Eldepryl[R]) are the MAOIs.
The MAOIs currently available in the United States are phenelzine (Nardil), isocarboxazid
(Marplan), and tranylcypromine (Parnate).
Sertraline and isocarboxazid
cause a serotonin syndrome.
There are three categories of these drugs: (1) TCAs (tricyclic antidepressants), which include imipramine (Tofranil) and amitriptyline (Elavil); (2) MAOIs (monoamine oxidase inhibitors), such as phenelzine (Nardil) and isocarboxazid
(Marplan); and (3) SSRIs (selective serotonin reuptake inhibitors), such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil).
Includes phenelzine oxidase, an enzyme that breaks (Nardil), isocarboxazid
antidepressant drugs such as isocarboxazid
, the Parkinson's medication selegiline, or the.
2) Lastly, because VMAT2 inhibition may alter synaptic levels of other monoamines, it is recommended that valbenazine not be administered with monoamine oxidase inhibitors, such as isocarboxazid
, phenelzine, or selegiline.
A recent meta-analysis2 found no benefit over placebo of the ADs paroxetine, fluoxetine, amitriptyline and isocarboxazid
- studied specifically in patients with 'minor' depression.
Monoamine Oxidase * Combining with too * Avoid excessive Inhibitors much caffeine, beer or caffeine; use with isocarboxazid
wine (even alcohol- caution.
Irreversible MAO inhibitors include phenelzine, tranylcypromine, isocarboxazid
, hypericin, and nialamide, all of which are non-specific.