The CYC400 CDK inhibitor
series has emerged from a pyrimidine basic chemical structure or pharmacophore.
Half received an ACE inhibitor
(most often enalapril) and half got a common diuretic (usually hydrochlorothiazide).
If used as the only protease inhibitor
in a regimen, the recommended dose of ritonavir is 600 mg (six 100 mg capsules) twice a day.
The Company's second-generation maturation inhibitor
program is designed to identify analogs of bevirimat with different pharmacological properties.
But he noted that in time the nucleoside-inhibitor
-only approach will lead to rebound -- so it might be necessary to restart the protease inhibitors
for some period of time, to take advantage of the fact that the protease inhibitors
can reduce the blood level of even resistant virus.
The Panel on Clinical Practices for the Treatment of HIV Infection classifies nelfinavir as a "strongly recommended" protease inhibitor
The Pan-Bcl-2 Inhibitor
GX15-070 Induces Apoptosis in Human Myeloma Cells by Noxa Induction and Strongly Enhances Melphalan, Bortezomib or TRAIL-R1 Antibody Apoptotic Effect" [Gomez-Bougie, et al.
Note: a "boosted" protease inhibitor
means that the drug is used in combination with another protease inhibitor
--often but not necessarily a small dose of ritonavir, which slows the body's metabolism of many drugs, thereby keeping the blood level of the other protease inhibitor
Emivirine (Coactinon), a non-nucleoside reverse transcriptase inhibitor
(NNRTI) in Phase III clinical development, was studied for pharmacokinetic interactions with zidovudine/lamivudine or zidovudine/indinavir.
He suggests that drugs that have failed as antibiotics in the past may be effective in combination with an efflux-pump inhibitor
In preclinical myocardial infarction studies employing coronary artery ligation, for example, treatment with a HIF-PH inhibitor
preserved heart function and improved survival rate2.
As with the protease inhibitor
Kaletra, a low dose of ritonavir has to be used with tipranavir to keep the body from rapidly destroying the drug.
A caspase inhibitor
added to brain cells containing these repeats prevented the cells from dying, says Yuan.
A statistical analysis found four independent predictors of progression to cirrhosis (severe scarring of the liver): absence of protease inhibitor
therapy (relative risk 4.
By using the COX-2 inhibitor
from which celecoxib was derived, cancer biologist Raymond N.