Given the metal concentrations at which Ape1 activity is inhibited (excluding localized accumulation) and the selective inactivation seen in cell extracts (Figure 5), it seems reasonable to conclude that Cd(II), Fe(II), and Pb(II) may promote their harmful effects through inhibition
of Ape1 repair function.
Taking into account these events, Bayer CropScience concluded that reliable human data would be necessary to refine the dose response and time course of cholinesterase inhibition
following exposure to aldicarb and to further investigate the relative sensitivity of humans compared to animals.
4] induced acute pulmonary vasoconstriction in perfused rabbit lungs and that this effect was associated with inhibition
of nitric oxide production (Huang et al.
Preclinical studies have also indicated that talabostat's inhibition
of FAP can enhance anti-tumor activity.
The results showed that luteolin blocked TCDD-induced luciferase activity in both cell lines, and these results were comparable with the inhibition
of TCDD-induced transformation of the rodent cytosolic AhR as previously reported (Ashida et al.
Also, we just filed two additional patent applications for our rust inhibition
5+]) and two major metabolites, MMA and DMA, on the inhibition
of acetylcholine-induced vasorelaxation (Figure 1B).
B1 cyclin tracking reveals that escape from Alchemix-induced cell cycle arrest in G2 is forcing some cells to enter polyploidy via an aberrant mitosis in keeping with topoisomerase II inhibition
In this section we review the molecular characteristics and the involvement in steroidogenesis of both the sterol 14[alpha]-demethylase (encoded by the CYP51 gene) and the aromatase (encoded by the CYP19 gene), and we summarize the results of inhibition
studies with azole compounds.
These elevations in media DA concentrations may involve PCB-mediated inhibition
of the membrane dopamine transporter (DAT).
Under the terms of the agreement, AMVAC will obtain license rights for the life of patents covering a wide range of compounds that have been shown to provide excellent sprout inhibition
In particular, they wanted to measure the no-effect level, the highest daily perchlorate dose a person can ingest without experiencing any inhibition
of iodine uptake.
Data presented by the Munshi laboratory showed (1) dose and time-dependent drug uptake, (2) telomerase inhibition
and (3) apoptotic cell death in two different human myeloma cell lines after exposure to low micromolar concentrations of GRN163L.
PBPK Model for Perchlorate-Induced Inhibition
of Thyroid Iodide Uptake
Two of the posters that are being presented at the AACR meeting describe the inhibition
of the HDAC enzyme activity that leads to tubulin and histone acetylation.