The molecularly targeted drug, imatinib, inhibits
Bcr-Abl and is an effective therapy in treating CML.
Gleevec, BMS-354825, PD-180970 and MLN-518 inhibit
the kinase KIT and some of its mutations, but not T670I, which has been known to cause resistance to Gleevec in the treatment of gastrointestinal stromal tumors (GIST).
How the drug inhibits
angiogenesis remains unclear.
Two of the presentations, "C-myc antisense phosphorodiamidate mopholino oligomer inhibits
lung metastasis in a syngeneic lung tumor model," and "WT1: a novel target for antisense mediated prostate tumor therapy," evaluate studies done by AVI scientists in collaboration with Oregon Health & Science University.
Our ongoing research using NEUGENE antisense technology to inhibit
viral infection represents an exciting potential alternative to current antiviral drugs.
No other microbicides known to inhibit
HPV infection worked as well at carrageenan's effective dose, says study co-author John Schiller, also of the National Cancer Institute.
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit
its activation of the IFN-beta promoter.
An unexpected finding was not only that the musks inhibit
these transporters in marine mussels but that the effect is longterm and persists up to 24-48 hr after removal of the musk compounds.
When the woman is taking antibiotics, sometimes the intestinal bacteria are inhibited
, which in turn inhibits
the usual re-absorption of estrogen.
This month's Nutrition Hotline concerns the safety of long-term fasting, and the substances in caffeinated beverages that inhibit
The way NSAIDs inhibit
the formation of prostaglandins is by inhibiting their precursor enzymes, cyclooxygenase (COX).
today announced it has been awarded a Small Business Innovation Research Program (SBIR) grant through the National Institute of Arthritis and Musculoskeletal and Skin Diseases for research aimed at developing products to inhibit
the formation of adhesions following tendon surgery.
Hernia Repair Patch is the Only to Inhibit
Adherence of 10 Different Bacteria and Resist Initial Biofilm Formation for 14 Days Post-Implantation
This invention provides a method of inhibiting PAK4 function comprising administering a ligand comprising an amino acid domain which binds to a GTP binding protein so as to inhibit
binding of the GTP binding protein to PAK4.
Specialists in cancer prevention said the finding that resveratrol might inhibit
cancer development suggested one more reason that eating lots of fruits and vegetables was associated with a reduced risk of cancer.