The benefit of reduced radiographic progression with infliximab
treatment came on top of a prior report from the same study that the addition of infliximab
led to a significantly better rate of "good " responses after 1 year of treatment, based on EULAR (European League Against Rheumatism) criteria (Lancet 2009;374:459-66).
announced that SB4 etanercept and SB2 infliximab
investigational biosimilar candidates sustained comparable safety profiles in 52- and 54-week clinical studies, respectively.
During this hospitalization, the 6-mercaptopurine and infliximab
were discontinued, but the patient remained on low dose corticosteroids.
Studies suggesting that AABs are less common at higher doses of infliximab
or adalimumab may not be accurate and may only reflect the limitations of the available assays for AABs.
1), 5mg/kg infliximab
treatment was planned for the baseline, 2nd and 6th weeks and in every following six weeks.
Clinical remission rates in the two studies were significantly greater among patients treated with infliximab
than among those who received placebo: In an 8-week study, which did not include patients who had previously been treated with a TNF blocker, the clinical remission rate at 8 weeks was 18.
33) In children, nonrandomized open-label studies of the TNF inhibitors etanercept and infliximab
have shown that these biologicals safely control active disease when used in combination with traditional therapies.
Sixty-six percent of the patients were found to use infliximab
, 34% etanercept and 20% adalimumab.
The patients were then randomized to treatment: 169 infliximab
monotherapy, 170 azathioprine monotherapy, or 169 infliximab
plus azathioprine combination therapy.
After 6 months, 60 percent of those who initially received infliximab
and azathioprine were free of Crohn's disease symptoms, while only 36 percent of those getting steroids first were.
Two months before presentation, she required hospitalization for partial small bowel obstruction, at which time infliximab
was started after a negative PPD skin test.
For patients with steroid-resistant or steroid-dependent disease, the use of infliximab
(a monoclonal antibody to TNF-[alpha] may help induce and sustain clinical remission, thus avoiding surgery.
NEW YORK -- Collectively hailed as the biggest breakthrough for psoriasis therapy in decades, infliximab
, etanercept, alefacept, and the other "targeted biologics" seem poised to revolutionize how dermatologists treat moderate to severe psoriasis.
A Health Board consortium of Greater Glasgow, Forth Valley, Lanarkshire, and Dumfries and Galloway, is currently carrying out a study into the clinical effectiveness of Infliximab
The study, published in the April 15, 2010 issue of the New England Journal of Medicine, found treatment of moderate to severe Crohn's disease with infliximab
plus azathioprine allows more patients to achieve remission and mucosal healing than therapy with azathioprine alone.