inclusion body


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Related to inclusion body: inclusion body disease
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  • noun

Synonyms for inclusion body

any small intracellular body found within another (characteristic of certain diseases)

References in periodicals archive ?
Inclusion body myositis, in Engel A, Franzini- Armstrong C (eds): Myology: Basic and Clinical.
and was soon convinced that inclusion body disease was worth going after.
Belo Horizonte virus: a vaccinia-like virus lacking the A-type inclusion body gene isolated from infected mice.
4,6,8,9) Inclusion body myositis is further distinguished pathologically from dermatomyositis by the lack of perifascicular atrophy and the absence of a B-cell--predominant perivascular inflammatory infiltrate.
No A-type inclusion body (ATI) was seen, reinforcing the conclusion that this virus was likely not a CPXV, but a VACV.
The report, in the September issue of the Journal of Molecular Neuroscience, disclosed that the oligonucleotides were found to retard inclusion body formation in a model neuronal cell line.
1) This finding subsequently resulted in the recognition of inclusion body myositis (IBM) as a unique pathologic entity.
Transgenic mice that make too much PrP eventually develop muscle disease, and last year other researchers found that people suffering from inclusion body myopathy, a muscular disorder, build up excess PrP in their muscles.
In May 2011, New Zealand Pharmaceuticals entered a collaboration with the National Human Genome Research Institute (NHGRI), part of the US National Institutes of Health (NIH), to take the investigational hereditary inclusion body myopathy (HIBM) therapeutic DEX-M74 through preclinical development and clinical trials.
Another clinical trial of the follistatin gene therapy in patients with inclusion body myositis is also being conducted at Nationwide Children's Hospital.
The potentially protective pathways of inclusion body formation will be explored using cryo-ET and laser capture dissection coupled with highly sensitive proteomics.
The clinical study, conducted at Nationwide Children's Hospital and funded by the foundation Parent Project MD, is also evaluating safety and efficacy in nine patients with inclusion body myositis.
The lead product, UX-001, a first-in-class therapy for treatment of Hereditary Inclusion Body Myopathy (HIBM), is expected to enter the clinic in 2011.
HRG is a non-profit organization dedicated to finding a treatment for Hereditary Inclusion Body Myopathies (HIBM).
The team also found that mutations in proteins called heterogeneous ribonuclear proteins (hnRNPs) caused an inherited disease in a small number of families with symptoms of ALS, the frontotemporal dementia, the muscle disease inclusion body myopathy, and the bone disorder Paget's disease of bone.