immunogenicity


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Related to immunogenicity: humoral immunity
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  • noun

Words related to immunogenicity

the property of eliciting an immune response

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The safety and immunogenicity of HB-101 were evaluated in a randomized, placebo-controlled, double-blind phase I dose-escalating trial (NCT02798692).
Modeled after Certara's highly successful Simcyp Consortium, and believed to be the first of its kind, the QSP Immunogenicity Consortium brings together biopharmaceutical companies in a pre-competitive environment to cooperatively develop an Immunogenicity Simulator that will predict immunogenicity of biologics and its impact on their pharmacokinetics, efficacy and safety in diverse patient populations.
After vaccination, in adults and older adults, the hemagglutination-inhibition titers fulfilled the European licensure criteria for immunogenicity.
Despite containing predominantly human sequences, these molecules may show structural features that are different from those of the endogenous proteins, such as glycosylation patterns that are characteristic of the producing cells [Chinese hamster ovary (CHO) cells or mouse myeloma cells] and not necessarily identical to the human glycosylation pattern, which may also contribute to immunogenicity (14).
Immunogenicity, suboptimal dosing, or imperfect adherence all can reduce response to a previously effective therapy.
The transaction not only expands BioAgilytix's global footprint, with IPM's newly planned GLP laboratory facility as its European headquarters, but also brings on board IPM's immunogenicity, pharmacokinetics, and pharmacodynamics expertise to complement BioAgilytix's capabilities in biomarkers, cell-based assays, and immunogenicity and pharmacokinetics.
The 2016 event will address the real challenges with immunogenicity including assay assessment, the role of aggregation, the introduction of nanobodies and much more.
Immunogenicity can be influenced by various factors, such as patient or disease-related factors and also product-related factors.
Antitope will use its EpiScreen technology, a highly accurate and sensitive ex vivo human T cell assay to determine the potential immunogenicity of the antibodies provided by Synthon.
Therefore, researchers all over the country look for new approaches to increase immunogenicity of the vaccine.
Under the terms of the agreement Annexon will provide antibodies against specific components of the complement system and Antitope will use its Composite Human Antibody technology to generate a series of fully humanised antibodies devoid of T cell epitopes and with a consequent low risk of clinical immunogenicity.
Under this agreement, Antitope will apply its Composite Human Antibody technology to generate fully humanised antibodies devoid of T cell epitopes with a consequent very low risk of clinical immunogenicity.
In what they described as the first randomized controlled trial assessing the immunogenicity of PCV13 in the four different immunization schedules "currently used in most high-income countries," all children vaccinated in all schedules achieved comparably high IgG seroprotection levels.