Dr Helmut Woelk and his German team studied patients being treated with either St John's Wort extract or imipramine
- one of the most commonly used anti-depressants.
, amitriptyline, clomipramine, and doxepin are tertiary amines.
They concluded that the efficacy of paroxetine and imipramine
did not statistically or clinically differ from placebo for any prespecified primary or secondary outcome measure.
These were all randomised, double-blind trials ranging from 6-8 weeks in duration, comparing saffron to placebo (two studies), fluoxetine (two studies) or imipramine
Tricyclics are similar to kynidin in that imipramine
is one of the indicater drugs .
The antidepressants tested were imipramine
, which modulates the activity of certain hormones causing mood disorders; and promethazine, a sedative, antiemetic, and antipsychotic drug.
Thus we investigated whether a standardized willow bark preparation (WB) which contains among other constituents salicin, the forerunner of non-steroidal antiphlogistic drugs, would have an effect in a standard model of depression, the forced swimming test (FST), compared to the antidepressant imipramine
The most commonly used drugs include desmopressin acetate which is a synthetic analogue of arginine vasopressin, imipramine
hydrochloride which is a tricyclic antidepressant and anticholinergics.
In a recently published study, a highly absorbable form of curcumin called BCM-95, from EuroPharma, Green Bay, Wl, was compared to fluoxetine (one brand name is Prozac) and imipramine
(one brand name is Tofranil) in an animal scientific model of depression and was found to be as effective in alleviating depression as either prescription drug.
In the antidepressants category, the panel found moderate evidence to support the use of amitriptyline, venlafaxine, and duloxetine (level B), weak evidence for adding venlafaxine to gabapentin for better response (level C), and insufficient evidence to support or refute the use of desipramine, imipramine
, fluoxetine, or the combination of nortriptyline and fluphenazine (level U).
20) By the turn of this century, researchers in Italy and Spain showed that SAMe reverses experimentally-induced depression in rats, at a rate faster than that of the prescription antidepressant imipramine
, the first tricyclic antidepressant developed, and without apparent side effects.
After other exclusions, the authors were left with just 6 trials of 2 drugs--paroxetine and imipramine
Three of the trials were of Paxil, from GlaxoSmithKline Plc, a so-called SSRI (selective serotonin reuptake inhibitor), and the other three were of imipramine
, an older generic drug from the class known as tricyclics.
3H] serotonin competition uptake assays with antidepressant compounds such as paroxetine, imipramine
, r-citalopram and scitalopram are currently underway to determine Ki values for various SERT-interacting compounds.
Tricyclic antidepressants (TCAs) such as amitriptyline, imipramine
, and less often nortriptyline can be used.