related to B cell depletion after rituximab treatment is not usually problematic and is not associated with any clinical morbidity Recently a prolonged hypogammaglobulinemia
was reported in some patients receiving the therapy as an adjuvant to autologous stem cell transplantation (19), (20).
The concept of Transient Hypogammaglobulinemia
was firstly announced to the English medical literature by Gitlin and Janeway (1956).
Prospective study of cancer in patients with hypogammaglobulinemia
Visceral leishmaniasis in a patient with acquired hypogammaglobulinemia
Common variable hypogammaglobulinemia
with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: different lymphocyte populations with a similar response to prednisone therapy.
Key Words: retinitis pigmentosa, hypogammaglobulinemia
, Sertoli cell only syndrome
The CHMP has recommended that Baxter's new IVIG be indicated for replacement therapy in primary immunodeficiency disorders, myeloma or Chronic Lymphocytic Leukemia (CLL) with severe secondary hypogammaglobulinemia
and recurrent infections, children with congenital AIDS and recurrent infections, Idiopathic Thrombocytopenic Purpura (ITP) in children or adults at high risk of bleeding or prior to surgery to correct the platelet count, Guillain Barre Syndrome, Kawasaki Syndrome and allogeneic bone marrow transplantation.
When any degree of hypogammaglobulinemia
is associated with significant recurrent bacterial infection, it suggests the need for replacement therapy with intravenous immunoglobulin, and the patient should be referred to a specialist for evaluation and follow-up.
Viral DNA also was detected in fecal specimens from the United States and The Gambia, and STLPyV has been found in a surface-sanitized skin wart surgically removed from the buttocks of a patient with a primary immunodeficiency called WHIM (warts, hypogammaglobulinemia
, infections, and myelokathexis) syndrome (11).
These abnormalities are hypogammaglobulinemia
, decreased T-cell numbers, and an elevated IgG level (22), (23).
The triggers for reflexing SPE results were abnormal discrete bands (M-spikes), fuzzy or questionable fuzzy bands, hypogammaglobulinemia
Many conditions other than bacterial overgrowth can potentially lead to alteration of small bowel mucosal architecture, including use of corticosteroids or other immunosuppressants, recent antibiotic use, zinc deficiency, alcoholism, hypogammaglobulinemia
, infection with enteric pathogens, and upper gastrointestinal Crohn disease.
Other diseases in which host defenses are altered have also been associated with the development of hyperinfection syndrome, including chronic alcoholism, malnutrition, burns, pancytopenia, hypogammaglobulinemia
, (1,2) and infection with HTLV-1 or HIV-1.
org 1,3,6 HYPERLIPODEMA See: Autoimmune Disorders HYPEROXALURIA See: Oxalosis & Hyperoxaluria HYPERTELORISM/ HYPOSPADIUS SYNDROMES See: Opitz Syndrome HYPERTHERMIA OF ANESTHESIA See: Malignant Hyperthermia HYPERTHYROID MYOPATHY See: Muscular Dystrophy; Thyroid Disorder HYPERURICEMIA-CHOREOATH ETOSIS-SELF-MUTILATION SYNDROME See: Lesch-Nyhan Disease HYPERURICEMIA, HEREDITARY See: Lesch-Nyhan Disease HYPODONTIA AND NAIL DYSGENESIS See: Ectodermal Dysplasias HYPOERYTHEMIA, PROGRESSIVE See: Anemia, Aplastic HYPOGAMMAGLOBULINEMIA
See: Immune Disorders HYPOMELANOSIS OF ITO See: Ectodermal Dysplasias; Epilepsy; Incontinentia Pigmenti; Vitiligo HYPOMYELINATION See: Myelin Disorders HYPOPARATHYROIDISM Hypoparathyroidism Association, Inc.
Nine cases of enteroviral encephalitis (1 caused by echovirus 13, 1 caused by coxsackievirus A16, 2 caused by enterovirus 71, and 5 caused by unknown enteroviruses) have been reported after therapy with rituximab, a monoclonal antibody (MAb) that causes secondary hypogammaglobulinemia