(excess calcium in the urine) is thought to be partially mediated through the insulin/ glucagon pathways, which are required to metabolize carbohydrates and can result in hypersaturation of urinary calcium with a concomitant increase in calcium-oxalate stone formation (as well as calcium urate and calcium phosphate).
Effects of a low-salt diet on idiopathic hypercalciuria
in calcium-oxalate stone formers: a 3-mo randomized controlled trial.
Hypercalcaemia is observed in up to 11% of patients; however, hypercalciuria
is more frequent (40% of patients) and renal calculi are not uncommon (10%).
In the granulomatous tissue, active form of vitamin D is produced and as a result of that hypercalcemia and hypercalciuria
Chronic acidosis causes bone resorption and impairs renal tubular reabsorption of calcium resulting in hypercalciuria
The second is Hereditary HR with Hypercalciuria
(HHRH); caused by mutation in the gene SLC34C3 encoding the renal sodium-phosphate co-transporter NaPi-IIc.
was likely an effect of the medications.
Hematuria associated with hypercalciuria
and hyperuricosuria: a practial approach.
Hypophosphatemia is associated with hypercalciuria
as seen in our patient (6).
Excess production of FGF23 epidermal naevus syndrome Abnormalities of renal Na dependent P co-transporter: Hereditary hypophosphataemic Inactivating mutation in rickets with hypercalciuria
SLC34A3 gene Other defects of renal tubular function: Fanconi syndrome Proximal renal tubular acidosis Distal renal tubular acidosis FGF23, fibroblast growth factor 23; PHEX, phosphate regulating gene with homologies to endopeptidases on the X chromosome; DMP1, dentin matrix protein 1; FRP4, Frizzled-related protein 4; MEPE, matrix extracellular phosphoglycoprotein; SLC34A3, type IIc sodium- phosphate co-transporter
6 Hypervitaminosis D is associated with increased absorption of calcium and phosphorus, which can lead to hypercalcemia, hypercalciuria
, vascular calcification, renal, and even renal failure.
Reduction of hypercalciuria
in tetraplegia after weight-bearing and strengthening exercises.
and altered intestinal calcium absorption occurring independently of vitamin D in incomplete distal renal tubular acidosis.
The only time that clinicians should be cautious is if patients have sarcoidosis or other chronic granulomatous disorders, because in those cases if the blood level is much above 30 ng/mL, the granulomatous tissue will independently activate vitamin D and it can result in hypercalcemia or hypercalciuria
," he explained.
Hypercalcaemia and hypercalciuria
after topical treatment of psoriasis with excessive amounts of calcipotriol.