A biopsy revealed he had Multisystem Langerhans cell histocytosis
, a cancer so rare that medics at the Children's Hospital only encounter a case once every two years.
Differential diagnosis included infectious diseases like osteomyelitis, central giant cell granuloma; inflammatory conditions like Rheumatoid arthritis, secondaries of jaws, osteogenic sarcoma; Histocytosis
, Stills disease, endocrine disorders like hyperparathyroidism that needed to be excluded.
Langerhans Cell Histocytosis
is so rare that there is no funding, statistics or research to help and support those suffering from it.
Systemic diseases associated with periodontitis with or without premature exfoliation of primary teeth may include Papillon-Lefevre syndrome, hypophosphatasia, leukaemias, Chediak-Higashi syndrome, Langerhan's cell histocytosis
, neutropenia and leukocyte adhesion deficiency.
Differential diagnoses included sarcoidosis, histocytosis
, or other granulomatous diseases; Erdheim-Chester disease; and lymphocytic hypophysitis, or most likely, a microscopic prolactinoma.