Unusual presentation of hairy cell
leukemia: a case series of four clinically unsuspected cases.
44-positive, CD 103-positive, CD25-positive, CD11c-positive, and CD123-positive cells, leading to a diagnosis of hairy cell
leukaemia is a long-term illness that develops slowly.
Although hairy cell
leukemia is predominantly a disease of bone marrow, spleen, and peripheral blood, occasional cases may involve the skin.
For B-cell LPDs other than CLL/SLL, several subtypes showed a cyclin D1/CD19 result in the low "MCL range" (RFI = 10-50), specifically one of the three hairy cell
leukemia samples, one of the five diffuse large B-cell lymphomas, and one of the four follicular lymphomas, and "borderline" (RFI = 5-10) in one of the three hairy cell
leukemia samples, three of five diffuse large B-cell lymphomas, one of five acute lymphoblastic leukemia samples, and one of two Burkitt lymphoma samples.
Elevated antibody levels to Epstein-Barr virus antigens in patients with hairy cell
leukemia compared to controls in relation to exposure to pesticides, organic solvents, animals, and exhausts.
A bone marrow biopsy revealed a patchy infiltrate of loosely spaced, medium-sized lymphocytes suggestive of hairy cell
The name hairy cell
stems from the microscopic appearance of malignant white blood cells, which in this disease have irregular hairlike projections.
Chronic lymphocytic leukemia Malignant lymphoma, leukemic phase Hairy cell
leukemia Large granular lymphocytic leukemia Prolymphocytic leukemia Plasma cell leukemia Adult T-cell lymphoma-leukemia Mycosis fungoides/Sezary syndrome
Caggiano and the staff pathologist, using an electron microscope, detected the hairy cell
leukemia--so called because under the microscope the white blood cells look as though they are covered by small hairs.
For instance, interferon is approved as an orphan drug for the treatment of hairy cell
leukemia, with a patient population of about 2,000.
This report provides information on the therapeutic development for Hairy Cell
Leukemia, complete with latest updates, and special features on late-stage and discontinued projects.
A bone marrow biopsy revealed hairy cell
leukemia (Figure 1b).
Ibrutinib, which goes by the trade name Imbruvica(TM), is a therapy that targets an enzyme, Bruton's tyrosine kinase (BTK), which promotes growth of a variety of B-cell cancers, including CLL, MCL, Waldenstrom's macroglobulinemia (WM), follicular lymphoma, diffuse large B-cell lymphoma (DLBCL), hairy cell
leukemia (HCL) and multiple myeloma.
One of the most successful is a fast-track system to decide disability and compensation for the Agent Orange-related presumed service connection for ischemic heart disease, hairy cell
and other chronic B-cell leukemias and Parkinson's disease thanks to a computerized claims system that streamlines the process.