Diffusible nitric oxide gas penetrates vascular smooth muscle and activates soluble guanylyl cyclase which catalyzes which catalyzes guanosine triphosphate to form cyclic guanosine monophosphate
(Da Silva Rde et al.
Another possible mechanism involves l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate
(cGMP) signaling pathway.
LINZESS binds to the GC-C receptor locally in the intestine, with no measurable blood plasma concentrations, resulting in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate
Sexual excitement sparked the release of the chemical into the body, boosting the production of guanosine monophosphate
, which smoothes the muscles inside the penis so it can fill with blood.
There are other ways smooth muscle cells in the penis can relax, resulting in an erection: During sexual arousal penile nerves release nitric oxide (NO), which activates the smooth muscle cells to release the messenger cyclic guanosine monophosphate
(cGMP) inside the cells.
Sildenafil is a selective vasodilator that prolongs the action of cyclic guanosine monophosphate
(cGMP) by selective inhibition of phosphodiesterase (PDE) type 5, of which the lung has a rich supply.
Known as cyclic guanosine monophosphate
, or cGMP, the chemical may also play a role in the normal control of any mammal's digestive system.
They found that Viagra, by elevating levels of a compound in cells called cyclic guanosine monophosphate
, or cGMP, actually encourages platelets to aggregate, thus amending 20 years of scientific claims that the compound acts to prevent platelet aggregation.
5) CGRP acts on endothelial receptors and activates a series of intracellular processes that ultimately lead to an increase in cyclic guanosine monophosphate
levels and resultant vasorelaxation.
Other authors propose that the defect in malakoplakia may be due to low levels of cyclic guanosine monophosphate
in mononuclear cells, resulting in deficient lysosomal bacterial degradation and the inability of cells to release the lysosomal enzymes.
The drug interferes with a signalling chain of the messenger cyclic guanosine monophosphate
(cGMP), which allows the inflow of blood and an erection.
To verify further the involvement of nitric oxide/cyclic guanosine monophosphate
signaling pathway, the L-NAME (an inhibitor of NO synthase) 100 [micro]M or MB (a soluble guanylyl cyclase inhibitor) 10.
Ularitide induces natriuresis and diuresis by binding to specific natriuretic peptide receptors (NPR-A, NPR-B and other natriuretic peptide receptors), thereby increasing intracellular cyclic guanosine monophosphate
(cGMP) helping to relax smooth muscle tissues, leading to vasodilation and increased blood flow.