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Granulosa cell tumors affect both the ovaries and the testis and are much more common in the former.
Clinical and prognostic factors in adult granulosa cell tumors of the ovary.
Mutation of FOXL2 in granulosa cell tumors of the ovary.
Adult-type granulosa cell tumors and FOXL2 mutation.
Congenital intraabdominal bilateral juvenile granulosa cell tumors of the testis associated with constitutional loss of material from chromosome 4.
Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival.
Granulosa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature.
Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor.
One can argue that this spindle cell component is truly another pattern of granulosa cell tumor (pseudosarcomatous pattern) or it might represent a fibrothecomatous component, taking into consideration that most granulosa cell tumors have at least some theca cells focally.
Our response to this question is that the majority of the tumor ([is greater than] 80%) consisted of unequivocal granulosa cells with the usual patterns seen in classic adult-type granulosa cell tumor.
In summary, adult granulosa cell tumor is considered a very rare testicular tumor.
Previous studies (7, 20, 21) showed that inhibin A was detected in 20% of mucinous tumors and 77% of granulosa cell tumors, whereas inhibin B was detected in 60% of mucinous tumors (21) and 100% of granulosa cell tumors.
The [alpha]C IFMA shows a similar or improved detection of mucinous and granulosa cell tumors compared with the RIA used previously.
However, tumor-associated trypsin inhibitor is less effective in detecting granulosa cell tumors.