In the cerebellum, PAS highlighted cytoplasmic granules in the granule neurons
, in the dentate nucleus, and particularly in the Bergmann glia.
Moreover, the number of granule neurons
of the hippocampus was higher by about 7% in choline alfosceratetreated than in control 24-month-old rats.
However, in the region of the brain known as the cerebellum, Atoh1 is active after birth in the fast-dividing granule neuron
precursor (GNPs) cells that eventually stop dividing and become mature granule neurons
The paper, entitled Generation of cerebellar granule neurons
in vivo by transplantation of BMP-treated neural progenitor cells, was submitted by researchers at Rockerfeller University's Laboratory of Developmental Neurobiology and Columbia University's Department of Biochemistry and Molecular Biophysics.
Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons