neurogenesis continues through adulthood, declining with age in rats and in humans (Altman and Das 1965; Gage 2000).
Mouse cerebellar granule cell
cultures were treated with MAM (100 [micro]M) or HN2 (1.
Selective loss of hippocampal granule cells
following adrenalectomy: implications for spatial memory.
Katsunori Kobayashi explained, "Some of the side effects associated with Prozac in humans, such as anxiety and behavioral switching patterns, may be due to excessive dematuration of granule cells
in the hippocampus.
concentration of cerebellar granule cells
was estimated using the [Cl.
85,86) In cerebellar granule cells
(CGC), these compounds effectively prevent cell death caused by MeHg intoxication as well as improve cell migration.
Interestingly, addition of the NMDA receptor antagonist MK801 protects cerebellar granule cells
against DE-71-induced cell death (Reistad et al.
sinensis water extract and its phenolic and alkaloid compounds have protective effects against glutamate- and NO donor-induced neuronal death in cultured cerebellar granule cells
(Shimada et al.
Incoming signals are transmitted by granule cells
in the dentate gyrus to pyramid cells in the CA3 region and from these to pyramid cells in the CA1 region.
In this study, Gilbertson and colleagues show that over-expression of CTNNB1 in those precursor granule cells
has no impact on the developing mouse cerebellum and does not lead to medulloblastoma.
Radiation-induced apoptotic and necrotic cell death of granule cells
and Purkinje cells were inhibited significantly by alpha-lipoic acid pretreatment.
As reported in this month's issue, a research group exposed cultures of immature neurons known as granule cells
and the more developed and more abundant astrocytes to sublethal doses of two well-characterized alkylating genotoxicants: methylazoxymethanol (MAM), a highly toxic compound synthesized from the poison found in plants called cycads, and nitrogen mustard (HN2), a chemotherapeutic agent.
In the present study, we examined the protective effects of KBG and its constituent medicinal plants against NO donors, sodium nitroprusside (SNP) and 2,2'-(hydroxynitrosohydrazino)bis-ethanamine (NOC18)-induced neuronal death in cultured rat cerebellar granule cells
When the team followed the structural changes in the hippocampus during the conditioning process, they found a large increase in the numbers of synaptic structures at the terminals of neurons called granule cells
, which have axons called large mossy fibres after the memories were formed.
Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells