As demonstrated in BENEFIT, BENEFIT-EXT showed that patient and graft survival
were similar between belatacept-treated patients at the approved dose (LI) (82% of 175) compared to cyclosporine-treated patients (80% of 184) at Year 3.
Treatment of clinical polyomavirus disease with antiviral drugs such as cidofovir or leflunomide has not been shown to improve graft survival
7] Using multivariate analysis, however, it was found that the only predictor of patient and graft survival
was %PRA prior to the second transplant.
Lower patient and graft survival
in older patients may be attributed to recipient factors, rather than to the origin of the kidney, based on the fact that the most common cause of graft loss was death," Dr.
Most importantly, the patient and graft survival
, which was high from the beginning, has continued to improve.
There remains a need for novel agents that can reduce the incidence of acute and chronic rejection: however, achieving large increases in long-term graft survival
will be challenging as most causes of graft loss are not due to a lack of efficacy of current immunosuppressants, but are due to medical complications, disease recurrence, non-adherence and most importantly, death with a functioning graft.
Urine NGAL levels measured a day following transplant predicted prolonged DGF, which had significantly worse one-year graft survival
(73 percent) compared with shorter DGF (100 percent).
Overall kidney transplant graft survival
rates were 91% at 1 year, 86% at 2 years, 71% at 5 years, 39% at 10 years, and 24% at 15 years (Table 2).
Analyzing United Network for Organ Sharing (UNOS) records, Boston Children's researchers looked at data compiled over a fifteen year period (1995-2010), studying the graft survival
rates of 62,190 first-time adult deceased-donor liver transplant recipients, 889 of whom received partial grafts from a split liver transplant.
Foster or promote graft survival
of the kidney transplant for candidates with the longest post-transplant survival who are likely to require additional transplants due to early age of ESRD (End stage renal disease); * Minimize loss of potential functioning years of graft through improved matching of recipient and graft survival
Secondary endpoints included: patient and graft survival
up to 12 months after transplantation, duration of delayed graft function, length of stay in hospital, primary non-function of the transplanted kidney, serum creatinine and clearance after transplantation, acute rejection and calcineurin inhibitor toxicity.
1c] levels, a lower rate of pancreas graft survival
, and a higher rate of acute pancreas graft rejection.
The Hospital's adult kidney and transplant program was also honored by the Scientific Registry of Transplant Recipients as the only center in the nation to achieve statistically higher than expected results in both patient and graft survival
at both one and three years after transplantation.
Data on graft survival
and mortality for adult recipients of split livers is currently being compiled for a separate study to be released soon.
Even for some transplants that would be expected to have a very long graft survival
, protocol biopsies performed in the first year may indicate the kidney is undergoing damaging inflammation, which is associated with increased risk for reduced function and graft survival
," observed Mark Stegall, MD, Mayo Clinic transplant surgeon.