9] In the normal glycolytic pathway
, FDG behaves similarly to D-glucose.
It has purposely and deliberately deactivated the major source of energy (ATP production by the TCA cycle) and has relied only on the glycolytic pathway
, turning off the TCA cycle.
Fluoride acts primarily by inhibiting enolase in the glycolytic pathway
This action is most clearly evident from the decrease in the enzymatic activities within the glycolytic pathway
and the inhibition of lactate production.
The influence of the energetics in tumor genesis and progression was hypothesized by Warburg  who showed increase in aerobic glycolysis and dependence of the glycolytic pathway
for production of ATP.
When oxygenation reaches low critical levels, conservative strategies favor reversible inhibition of the glycolytic pathway
, coupled with additional substrate-level phosphorylations (Hochachka & Somero 2002).
The glucose so produced or the glucose absorbed from diet undergoes a series of reactions through anaerobic glycolytic pathway
in the tissues to produce pyruvic acid and then lactic acid or the pyruvic acid undergoes oxidative decarboxylation to form acetyl Co-A which is channelised into aerobic Kreb's cycle, which in its cycle generates reduced nucleotides (NADH and FAD) for the ultimate generation of biological currency, ATP through electron transport system.
I assumed that the inhibition of aerobic oxidation was compensated by the increased intensity of the anaerobic glycolytic pathway
of energy supply for maintenance.
The up-regulation of the glycolytic pathway
may be beneficial for cell survival, and if Ni(II) exposure is prolonged, it may select cells that maintain a high glycolytic rate and thereby acquire a phenotype similar to cancer cells, as described by Warburg (1956).
4) Phosphofructokinase is an allosterically regulated enzyme of the glycolytic pathway
Agios scientists discovered novel compounds that effectively increase activity of a cancer-associated isoform of pyruvate kinase (PKM2) in the glycolytic pathway
, which is a conserved metabolic pathway that processes sugar to fuel cell growth.