In its practice bulletin, ACOG noted that oral antidiabetic medications, such as glyburide
and metformin, are increasingly used among women with GDM, despite not being approved by the Food and Drug Administration for this indication and even though insulin continues to be recommended as first-line therapy by the American Diabetes Association (ADA).
For metformin and glyburide
, each agent alone lowered glycated hemoglobin ([HbA.
The company has received approval of generic glyburide
tablets, which was developed at its Middlesex, NJ facility.
A Malaysian study in 1997 was the one of the first to report favorable outcome of the use of glyburide
in pregnant women, study was done in comparison with insulin.
Newborns of women treated with glyburide
were at increased risk for admission to the neonatal intensive care unit, respiratory distress, hypoglycemia, birth injury, and large for gestational age, compared with newborns of mothers treated with insulin.
15 The incidence of neonatal hypoglycaemia was slightly less and birth weight was also slightly lower with metformin as compared to insulin, and slightly high with glyburide
as compared to insulin.
Other research, though, suggests that three diabetes drugs, including glyburide
, may raise your risk of death if you also have heart disease.
Among the 2,721 subjects with documented coronary artery disease (CAD), glipizide and glyburide
carried an increased overall mortality risk compared with metformin, but glimepiride did not, said Dr.
Researchers evaluated "data from nearly 24,000 patients with type 2 diabetes, average age 62, who were treated with one of three drugs called sulfonylureas (glipizide, glyburide
, and glimepiride) or with another type of drug called metformin.
The drugs, glipizide, glyburide
, and glimepiride, are known as sulfonylureas, which help decrease blood-sugar levels among type 2 diabetes patients by stimulating the pancreas to produce insulin.
In this meta-analysis, clinical heterogeneity likely exists because glyburide
and metformin have entirely different modes of action.
The most common oral hypoglycemic agents used in pregnancy include metformin and glyburide
5 to 12 mg/d achieved a significantly lower PPG level after 12 months than did those treated with glyburide
5 to 20 mg/d (148 vs 180 mg/dL; P<.
And the common diabetes drug glyburide
blocks the destructive SUR1 protein made by the gene.
A major study published in 2000 found glyburide
worked well in pregnant women and did not cross the placenta, so it had no obvious ill effects on the baby.