It is time to reassess the question and ask "What test best identifies glucose toxicity
for the fetus?
Most of the insulin resistance in patients with type 2 diabetes is linked to obesity (associated with defective leptin action), reduced physical activity, glucose toxicity
and high-fat diets.
EFFECT OF GLUCOSE ANALOGUES AND GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY
IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Specifically, we assessed: (1) deoxyglucose uptake in differentiated C2C12 muscle cells and 3T3-L1 adipocytes; (2) glucose-stimulated insulin secretion (GSIS) in beta TC-tet pancreatic beta cells; (3) beta cell proliferation in beta TC-tet cells; (4) lipid accumulation in differentiating 3T3-L1 cells; (5) protection against glucose toxicity
in PC12 cells.
Beneficial effects of antioxidants in diabetes; possible protection of pancreatic beta-cells against glucose toxicity
This finding might be of relevance to the natural history of type 2 diabetes because glucose toxicity
attributable to chronic hyperglycemia per se impairs both insulin action and insulin secretion (32).
Since we are dealing with children and adolescents, whose blood sugars have not been high for long, this approach can rapidly eliminate glucose toxicity
, and we think their beta-cell function is then restored," Elizabeth Sellers, M.