The pathway for this appears to be impaired negative feedback regulation of HPA axis function and glucocorticoid resistance
(determined by the dexamethasone suppression test).
However, the constant increase in the number of patients suffering from glucocorticoid resistance
could present a serious problem for clinicians.
is analogous to insulin resistance as found in type 2 diabetes: the more that the hormone is around, the less the body cells respond to it.
8-10) The molecular basis of generalized glucocorticoid resistance
has been ascribed to mutations in the hGR gene, which impair one or more of the molecular mechanisms of hGR action, thereby altering tissue sensitivity to glucocorticoids.
used gene expression patterns to identify that rapamycin in combination with glucocorticoids could be used successfully in cancer treatment to combat glucocorticoid resistance
People who didn't carry these polymorphisms appeared to show some glucocorticoid resistance
and also "seemed to be protected from the development of PTSD symptoms in a gene-dose dependent manner," the investigators noted.