Safety of low dose glucocorticoid
treatment in rheumatoid arthritis: published evidence and prospective trial data.
For Duchenne muscular dystrophy (DMD), Santhera has filed a Marketing Authorization Application in the European Union and Switzerland for DMD patients with respiratory function decline who are not taking glucocorticoids
Their report, published in Arthritis Care & Research, does not address intra-articular administration of glucocorticoids
Sean E Harper, MD, executive vice president of Research and Development at Amgen, said, 'The impact of glucocorticoid
therapy on bone strength is frequently underestimated, and often leads to increased bone loss and ultimately, a fracture.
Higher levels of glucocorticoid
receptor (GR) gene promoter methylation at pretreatment (indicating lower GR expression) were associated with a positive response to psychotherapy treatment.
injections are widely used to treat rheumatoid arthritis and other joint diseases, they have been recognised to be harmful to cartilage over prolonged use, possibly due to inhibiting effects on the development of cartilage cells from stem cells.
This is the first study to uncover the role played by glucocorticoids
We studied the rhythmic expression of clock genes in white blood cells to see how they adjusted in response to glucocorticoids
However, these effects occur at much higher concentrations than those used in this study (10-100 [micro]M); when the results of the receptor knockdown experiments are considered, the glucocorticoid
antagonist properties of Gen appear to be mediated through ER[alpha] for those genes studied (Barnes et al.
receptor dimers bind to glucocorticoid
recognition elements to activate or to inhibit corticoid-sensitive genes via mechanisms known as trans-activation and trans-repression.
Accelerated atherosclerosis in systemic lupus erythematosus has been attributed to the disease or to glucocorticoid
plus lidocaine injections were associated with more adverse effects (21.
Although considered rare, the true extent of glucocorticoid
induced reactions is unknown and no uniform mechanism has been identified.
secretion enhances a patient's coping mechanisms by helping them process information in a way that diminishes retrieval of fear-evoking memories.
Via observation ofbehaviour and measurement of faecal glucocorticoid
metabolites (FGM), our research focused on the capture and reintroduction of Przewalski'shorses (Equus ferus przewalskii).