Morphometric investigations showed that in this test group (test 2) the size of renal corpuscle and the size of its glomerulus
Glomerular filtration: As blood passes through the glomerulus
, components are filtered to form the renal filtrate.
Cystatin C is produced by all nucleated cells, and is freely filtered at the glomerulus
and completely metabolized by the tubules.
Blood colloid osmotic pressure (due to protein that cannot filter out) pulls fluid back into the glomerulus
and is like students returning to the classroom to collect forgotten keys and cell phones.
Figure 2 demonstrates a glomerulus
from a biopsy of a patient with severe lupus flare.
Nil disease refers to the presence of little or no inflammatory changes in the glomerulus
by light microscopy.
Kidneys remove toxins and waste products from the blood by filtering it across a delicate membrane in a structure called the glomerulus
5] Thus, small, positively charged molecules pass freely through the glomerulus
The kidneys filter the blood in the glomerulus
(a network of small blood vessels), and the filtered fluid is passed into the tubule, where it is either reabsorbed into the bloodstream or excreted as urine.
Diabetic nephropathy is a disease of the kidney glomerulus
and happens to be one of the most significant complications in terms of mortality and morbidity for patients with diabetes.
For morphometric analyses, positive cell numbers or positive signal areas per one glomerulus
in a total of 40 glomeruli was determined using Image J software (NIH, Bethesda, MD, USA).
Another important concept in the pathogenesis of diabetic nephropathy is that hyperglycemia impairs autoregulation within the glomerulus
by activating the local, intrarenal renin-angiotensin-aldosterone system, thus, compounding the hyperglycemia-induced injury.
Blood enters the glomerulus
through the afferent arteriole and exits via the efferent arteriole.
Moreover, creatinine is not only filtered at the glomerulus
, but is excreted in the tubules and thus does not behave as an ideal marker of GFR.
Five measurements from each glomerulus
were made utilizing the Image Pro Software.