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The sensitivity, specificity, positive predictive value, and negative predictive value of p63 immunohistochemistry for the diagnosis of giant cell tumor of bone were 86.
This study failed to reproduce the results of 2 previous studies portraying p63 as a potential diagnostic marker of giant cell tumor of bone.
Osteoblastoma and giant cell tumor of bone are usually easy to distinguish.
Following are important features to be cognizant of: (1) virtually any bone can be affected; (2) it commonly involves the spine, where it has a strong propensity to involve the dorsal vertebral elements as opposed to the body; (3) it can sometimes show locally aggressive growth, which correlates mostly with surgical resectability and possibly with specific histologic features such as prominent epithelioid cell morphology ("aggressive osteoblastoma"); (4) other benign tumors such as osteoid osteoma, aneurysmal bone cyst, giant cell tumor of bone, and sino-orbital osteoma can mimic it histologically; and (5) distinguishing it from osteoblastoma-like osteosarcoma, on the basis of careful evaluation of sometimes subtle cytoarchitectural features, is essential to avoid a misdiagnosis.
About Giant Cell Tumor of Bone GCTB is a locally aggressive, benign tumor afflicting younger adults between the ages 20 to 40.
4] Giant cell tumor of bone is believed to be of monocytic or histiocytic origin, and the presence of giant cells is attributed to fusion of the mononuclear cells.