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Most lung carcinomas with components of spindle cell and/or giant cell carcinoma are histologically heterogeneous.
In addition to the spindle and/or giant cell carcinoma patterns, when a component of adenocarcinoma or squamous cell carcinoma is present in a pleomorphic carcinoma, it should be documented (for example, pleomorphic carcinoma with squamous cell carcinoma, spindle cell and giant cell carcinoma) (Figure 2).
The 1981 World Health Organization's Histological Typing of Lung Tumours (12) recognized spindle cell carcinoma as a variant of squamous cell carcinoma; giant cell carcinoma as a variant of large cell carcinoma; and carcinosarcoma and pulmonary blastoma as miscellaneous malignant tumors.
Giant cell carcinoma is a non-small cell carcinoma solely comprising anaplastic, giant tumor cells (Figure 2, D).
Cases with a diagnosis of small cell carcinoma, mixed non-small cell and small cell lung carcinoma, giant cell carcinoma, mucoepidermoid carcinoma, sarcomatoid carcinoma, and basaloid carcinoma were excluded.