While it remains unclear whether the human species will suffer over the long term from the manipulation of genetic structures in the germ line
, there are substantial unknowns attendant to the long-range impact of genetic modification accompanied by cloning.
He has said that there is nothing in principle wrong with germ line
engineering, even with enhancing the human being," he said.
Because the genetic correction will be passed on to one's descendants, germ line
therapy is surrounded by a major debate.
Other, even more compelling questions relate to how society would assess the potential benefits and risks of a successful germ line
intervention in the context of various social and ethical considerations.
The question of the use of fetal germ line
stem cells, derived from spontaneously- or voluntarily-aborted early (i.
There are four types of human gene transfer that are likely to be developed as a result of the Human Genome Project: somatic cell therapy, germ line
therapy, somatic cell enhancement, and germ line
This type of human genetic engineering, usually referred to as germ line
gene therapy, is regarded by some as the best means to correct severe hereditary defects such as thalassemia, severe combined immune deficiency, or cystic fibrosis.
The germ line
transcends generations, the individuals of which grow old and die but live on in the biological sense through their progeny.
The iPCs were de-differentiated with non-viral methods into forming germ line
precursor cells which include genetic material that may be passed on to a child.
He calls them "passenger mutations in the germ line
," contrasting them with the "driver mutations" that propel the cancer process.
Transposon silencing in the Caenorhabditis elegans germ line
by natural RNAi.
Fukuyama warns that although human germ line
genetic engineering may be 50-100 years off, it is by far the most consequential of the four biotechnology-driven pathways to humankind's future because of its potential for permanently altering human nature itself.
It contains only one noticeable error (the arrows indicating the germ line
bands in Fig.
Chapter 7: Germ Line
Polymorphisms and Drug Response (Dimitri Semizarov).
In the latest study, they identified that the DUX4 protein regulates many genes that are normally expressed in the male germ line
but are abnormally expressed in FSHD muscle.