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  • noun

Words related to carcinogen

any substance that produces cancer

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Studies involving initiation with the genotoxic carcinogen azoxymethane, followed by quantitation of the number of aberrant intestinal crypts formed in response to subsequent carrageenan exposure, have also suggested that degraded carageenan has the potential to promote colon cancer in rats (3).
After treatment of mice with DDT for six generations at four doses, no increase in the incidence of liver tumors was observed from generation to generation, as might have been expected in the presence of a genotoxic carcinogen (67).
Animal models indicate it takes a promoter or some genotoxic carcinogen to get arsenic to produce skin cancers," says Michael Waalkes, section chief of the Inorganic Carcinogenesis Section at the National Cancer Institute Laboratory of Comparative Carcinogenesis, housed at the NIEHS.
However, in the present study, which was shorter term and used a lower dose, we found no change in oxidative DNA-damage-related gene expression, nor did we find a gene expression profile characteristic of a range of genotoxic carcinogens, such as described by Ellinger-Ziegelbauer et al.
Often being found in baked, fried or grilled foods, acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment states that exposure to genotoxic carcinogens should be as low as reasonably possible.
The ready quantifiable nature of sister chromatid exchanges with high sensitivity for revealing toxicant-DNA interaction and the demonstrated ability of genotoxic chemicals to induce significant increase in sister chromatid exchanges in cultured cells has resulted this endpoint being used as indicator of DNA damage in blood lymphocytes of individuals exposed to genotoxic carcinogens [1].