The new gene switch
already works in cultured cells and in selected tissues of genetically engineered mice.
Tomlinson further stated, "The availabilty of a positive, and now also a negative, gene switch
to regulate gene function in a tissue-specific manner advances further the potential use of this technology for analyzing the biological functions of genes in genomics research.
GeneMedicine believes that the gene switch
will allow gene expression to be controlled without any significant, adverse effect on other functions within the body.
Oxford BioMedica's RetinoStat(TM) is a LentiVector gene delivery system expressing an angiostatic gene under the control of its proprietary hypoxia response element gene switch
With the work accomplished already this year, Genelabs has laid the groundwork for the discovery of its first therapeutic lead compound and is pursuing additional corporate collaborations in the areas of drug discovery and agricultural applications of its gene switch
A gene switch
has already been produced and tested by Genelabs.
In these studies, the gene switch
functioned in vivo to provide drug-controlled expression of a gene medicine.