After stabilisation, gallamine
was administered and the depression of thumb muscle tension and the subsequent recovery were recorded.
In contrast, gallamine
(a non-depolarizing muscle relaxant) or the venom of the puff adder Bitis arietans reduced the force of contraction.
Sprague-Dawley rats were anesthetized with isoflurane, paralyzed with gallamine
, artificially ventilated and instrumented to record arterial blood pressure (BP; mm Hg), heart rate (HR; bpm) and left ventricular dP/dt (percent change from control; LVC; an index of cardiac contractile force).
Presumably its use in Operation Desert Storm would be to protect persons from the effects of a type of nerve gas; it is already approved by FDA for use as an antidote to curariform drugs and gallamine
triethoxide, drugs that have toxic effects related to those of the nerve gas in question.
At the start of my training in 1962 suxamethonium was widely used for intubation, as the two non-depolarizing relaxants curare and gallamine
in doses that would lead to easy and early reversal provided prolonged intubation times.
02% tricaine, immobilized with a 2-[micro]l injection of 1% gallamine
triethiodide (Flaxidil), and placed on their sides on a small sponge over a silver chloride pellet reference electrode.
The response to suxamethonium and gallamine
was largely unaltered by halothane, but with d-tubocurarine, profound bradycardia and hypotension occurred, and also to a lesser extent with neostigmine.
Tubocurarine was the drug of choice for operations of any significant duration, but because tubocurarine lasted around thirty minutes, gallamine
was often preferred for shorter operations.