Burns that generally can be managed in an outpatient setting include partial-thickness burns covering less than 15% of the total body surface (10% for children) and deep partial-thickness or full-thickness burns
covering less than 3% percent of the total body surface.
Initially, all partial- and full-thickness burns
should be covered with a sterile dressing, following a thin layer of topical antibiotic.
Director of The Burn Center of The Medical College of Virginia, reported that AlloDerm may provide clinical benefit when used as the initial graft for full-thickness burn
wounds in elderly patients.
The current treatment of choice for full-thickness burn
injuries is to transplant skin (autograft) from an uninjured portion of the patient to the burn site.
Studies published in 1993 in the Journal of Burn Care Rehabilitation revealed that this bacterial enzyme, when formulated in a hydrogel, was capable of rapidly hydrolyzing full-thickness burn
wounds in pigs.
The study reported AlloDerm sites demonstrated consistently high `take' rates and highlighted that the use of AlloDerm "would markedly reduce the amount of donor skin required for split-thickness autografts in full-thickness burn
The company announced in August that it had signed a cooperative research-and-development agreement with the Army Institute of Surgical Research and Rutgers University to expand development of its skin replacement product--known as engineered skin substitute (ESS)--for victims with deep partial and full-thickness burns
Acellular dermal tissue is used clinically in the treatment of partial and full-thickness burns
, traumatic tissue loss due to injury and for chronic wounds such as pressure ulcers, diabetic foot ulcers and venous and arterial ulcers.
works is Professor Graziella Pellegrini , Coordinator of cell therapy at CMR, as well as director of R&D and co-founder of Holostem, who authored, together with Professor De Luca, the research and designed the product development: "After developing cell cultures based on epithelial stem cells for the treatment of various disorders of the stratified epithelia - from the skin for full-thickness burns
to the reconstruction of the urethra - we discovered that the stem cells that allow the regeneration of the cornea reside in a small area at the border between the cornea (the transparent part at the center of the eye) and the conjunctiva (the contiguous white part), which is called 'the limbus'.