To guide selection of carbapenems or fourth-generation cephalosporins
as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum [beta]-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods.
In the United States, where fourth-generation cephalosporins
have not yet been approved for use in animal agriculture, resistance traits to these drugs are rare.
As a fourth-generation cephalosporin
, Maxipime's unique characteristics may offer advantages over other antibiotics.
Food and Drug Administration (FDA) of Maxipime(R) (cefepime hydrochloride) for Injection -- the only FDA-approved fourth-generation cephalosporin
antibiotic -- for the use in pediatric patients age 2 months to 16 years.
The risk of reaction with the newer third-and fourth-generation cephalosporins
is extremely low-in the order of 1-2%.