By considering the follicular adenomas
with the malignancies, the yield is improved to 78.
A subtotoal thyroidectomy was performed because of the compressive symptoms, which indicated a follicular adenoma
While cytology is performed preoperatively in nearly all thyroid gland nodules, making a definitive distinction between follicular adenoma
and carcinoma cannot be reliably or predictably achieved by fine-needle aspiration analysis, even with adjunct molecular evaluation.
11,105,108) Follicular adenomas
positive for PAX8/PPAR[gamma] typically have a thick capsule and show the immunohistochemical profile characteristic of thyroid cancer, suggesting that these tumors may be preinvasive (in situ) follicular carcinomas or malignant tumors for which invasion was overlooked during histologic examination.
6-mm diameter representing various thyroid nodules (27 goiter, 26 follicular adenoma
, 8 follicular carcinoma, and 14 thyrotoxicosis), 5 normal thyroids, and 20 tissue cores from a wide variety of nonthyroid tissues on a single recipient paraffin block in a 24 X 18 grid (406 cores with several blanks) using 2 to 5 cores per donor block (Figure 1, A).
Oncogenes and tumor suppressor genes in thyroid tumors Contributory genetic Neoplasm abnormalities Autonomously TSH receptor-activating functioning mutation; Gs-a mutation thyroid nodule decreasing GTPase activity Nodular goiter Many nodules are (colloid nodules) monoclonal, but precise gene abnormalities are unknown Follicular adenoma
RAS mutations Papillary thyroid BRAF (V600E) activating carcinoma mutation; RET rearrange- ments (RET/PTC); NTRK1 rearrangements (TRK); 14q13.
of Pittsburgh Medical Center), Biddinger (anatomic pathology, Medical College of Georgia) and Thompson (pathology, Southern California Permanente Medical Group) describe the normal anatomy and histology of the thyroid gland before exploring such conditions as diffuse and nodular hyperplasia, follicular adenoma
, medullary carcinoma and common mestatic tumors.
Two cases diagnosed cytologicaly as benign follicular cells while histopathological diagnosis revealed Follicular carcinoma as a result cytological diagnosis of follicular adenoma
Postoperative histopathology showed that colloid goiter, malignancy, and follicular adenoma
were the most common findings in the transient group, while malignancy and Hashimoto thyroiditis were the most common findings in the prolonged group.
Using the classification scheme in place when the study was begun, the microscopic diagnoses of the biologically malignant cases were papillary carcinoma (n = 7; 4 of which would currently be reclassified as anaplastic carcinoma), follicular carcinoma (n = 1, based on widespread vascular invasion), follicular adenoma
(n = 17), and "normal" thyroid tissue (n = 1).
Therefore, the diagnosis of noninvasive, encapsulated FVPTC versus follicular adenoma
is prone to considerable interobserver variability.
Benign lesions 82 (76) 22 (59) Hyperplastic nodules 34 (31) 3 (8) Follicular adenoma
42 (39) 3 (8) Hurthle cell adenoma 6 (6) 16 (43) Malignant lesions 26 (24) 15 (41) Follicular carcinoma 15 (14) 2 (5) Hurthle cell carcinoma 2 (2) 8 (22) Papillary carcinoma 9 (8) 4 (10) Other carcinoma 0 1 (3) Cytologic Diagnosis Suspicious for PC Suspicious for MC (n = 34) (n = 1) Histologic Diagnosis Cases, No.