, whether supplemental B vitamins or natural folates
found in food, are essential for the proper functioning of all cells in the body and are critical to prevent birth defects.
The study shows for the first time that an adult stem cell population is controlled by an external factor arising from outside the animal--bacterial folate
The major forms of folates
found in food are methylTHF and formylTHF.
While natural folates
are found in various food products, they can be unstable and easily damaged during processing, according to the company.
The researchers have focused on vitamin B9, also called folate
, found in a range of green leafy vegetables, cereals, fruit and meats, and have discovered that the father's folate
levels is very important to the development and health of their offspring.
are a mixture of a variety of isomers of the 5-methyltetrahydrofolate polyglutamates.
The rationale was to improve folate
status in women of childbearing age and thereby decrease the incidence of neural tube defects (NTDs).
Belgian scientists studied the mechanisms and kinetics of vitamin stability, specifically folate
stability, during high-pressure processing.
Data from the 1999-2000 National Health and Nutrition Examination Survey (NHANES) indicated that median serum folate
* concentrations in nonpregnant women of childbearing age had increased substantially, compared with concentrations during a period (1988-1994) before fortification was mandated (1).
Finding that the combination of high blood folate
levels and low vitamin [B.
occur predominantly as polyglutamylated molecules with a short [gamma]-linked chain of glutamyl residues attached to the first glutamate.
An ARS-funded study published this year revealed details about associations between low folate
levels and various stages of depression.
The most likely explanation, these researchers say, "lies in the known increased bioavailability of folic acid ove r [natural] food folates
This is consistent with the established use of reduced folates
for treatment of methanol/CHO toxicity.
The patent, "Methods of Producing Edible Fungi Containing Activated Folates
and Nutritional Supplements Containing Activated Folates
" details how edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate
) into edible portions of the plants.