Our patient had focal necrosis
and had none of the common laboratory findings consistent with BMN.
, mild pleomorphism, and plasma cells can be seen.
8) Histologically, they appear more aggressive, with nuclear pleomorphism, cytologic atypia, increased mitotic activity, focal necrosis
, and lymphatic/vascular invasion.
While many patients with severe class III may exhibit focal necrosis
(karyorrhexis) or extracapillary proliferation (crescents), these findings are not required for staging a particular biopsy as class III or class IV.
Necropsy indicated that the gray brocket deer had pulmonary congestion and edema, mild renal congestion, and renal focal necrosis
Microscopically, this tumor features pleomorphic oncocytes with increased mitosis, focal necrosis
, perivascular and perineural invasion, and an infiltrative growth pattern.
In the center of the solid growth was focal necrosis
, which frequently fused into a large area of geographic necrosis.
Biopsy samples contained epithelioid granulomas and a nonspecific, amorphous eosinophilic material without focal necrosis
, but no bacteria, by using periodic acid-Schiff, Ziehl-Neelsen, and auramine-rhodamine stains.