These preliminary findings provide additional evidence of the importance of early surgery for intractable focal epilepsy
, but their significance with respect to reproduction is uncertain given the small number of patients, she said.
Lesser RP, Dinner DS et al 1987 Benign focal epilepsy
of childhood In: Luders H, Lesser RD, eds.
Patients with refractory focal epilepsy
, who are candidates for surgical resection of the epileptogenic focus, frequently benefit from SPECT and/or PET imaging.
Monozygous concordance rates for focal epilepsy
The researchers analyzed data gathered from four patients with focal epilepsy
- seizures that originate in abnormal brain tissues - that could not be controlled by medication.
Other symptoms to be expected in benign brain tumours would include headache, vomiting, visual deterioration (papilloedema), focal symptoms (like focal epilepsy
, monoplegia, deafness and aphasia), dizziness, personality changes and mental deterioration.
Of these, 21 children had symptomatic focal epilepsy
, a further 17 symptomatic generalised epilepsy and one other child had epilepsy undefined as focal or generalised (Table 1).
For patients with drug-resistant focal epilepsy
, surgery is an increasingly common alternative and MEG is proving useful for locating epileptogenic zones in relation to other functionally important areas of the brain.
Neurologic manifestations of the disease in our patient comprised focal epilepsy
and myopathy, manifesting as muscle cramps, myalgias, double vision, weakness, reduced tendon reflexes, exercise intolerance, CK elevation, abnormal ischemic forearm test, myogenic EMG, and abnormal muscle biopsy.
Diacrin, to whom MGH has exclusively licensed this breakthrough technology, is currently utilizing it in clinical trials involving the transplantation of porcine brain cells into sufferers of devastating neurological conditions, including Parkinson's disease, Huntington's disease, and focal epilepsy
Physicians determine the focus by visual inspection of the EEG (typically in 10 sec segments) seeking focal epilepsy
characteristics such as interictal epileptiform discharges and seizure origination brain sites.