such as haloperidol, fluphenazine, and chlorpromazine were used by 2.
The adolescents were all managed in adult psychiatric wards, and the majority of patients were initiated on first-generation antipsychotics
Until recently, only first-generation antipsychotics
were available as long-acting injections.
Looking at differences between patients treated with first- and second-generation antipsychotics is more difficult, but there appears to be an increased association of diabetes with second-generation antipsychotics than with first-generation antipsychotics
, although the data are mixed on this point.
Its investigators concluded that use of first-generation antipsychotics
presented "no disadvantage," compared with the second generation.
Second-generation versus first-generation antipsychotic
drugs for schizophrenia: A meta-analysis.
Other studies have demonstrated higher fasting and postprandial plasma glucose levels in patients treated with olanzapine or clozapine than those treated with first-generation antipsychotic
medications, even when controlling for body weight.
Antipsychotic-induced tardive dyskinesia is a potentially irremediable and debilitating condition with the onset most commonly associated with the use of first-generation antipsychotics
This randomized study compared the effectiveness of several second-generation antipsychotics (SGAs) to one of the first-generation antipsychotics
Shon and TMAP, charging that pharmaceutical companies donated hundreds of thousands of dollars to the development of the algorithms in an effort to promote the use of atypical antipsychotics over first-generation antipsychotics
, even if clinicians might prefer using the older drugs.
While weight gain was associated with first-generation antipsychotics
, data regarding other metabolic effects are not available.
5%), be taking first-generation antipsychotics
The older, first-generation antipsychotics
in particular can cause symptoms similar to those in Parkinson's disease, including obvious tremors and involuntary body movements.
6% of the overall sample of children and adolescents also received first-generation antipsychotics
Some behavioral health leaders and government policymakers believe the first-phase results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) justify a look back at first-generation antipsychotics
("typicals") as viable first-line treatments for schizophrenia.