The 8-year outcome of the trabeculectomy has demonstrated that the visual function in PG eyes can be well-preserved after the filtration surgery
A randomized study of 5fluorouracil and filtration surgery
Even though these complications were those inherent to filtration surgery
, the cataract removal technique may well influence the results.
PRM-151 is also being tested in a Phase 2a clinical study to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery
Indications for Filtration Surgery
: Patients with exfoliation glaucoma were mainly subjected to filtration surgery
due to failed medical therapy; which was either due to continued raise in intraocular pressure (>21mmHg) despite maximal tolerable medical treatment (60%); or due to both increased intraocular pressure and continued field loss (16%); or intolerance to medical therapy (12%); or due to progression of visual field loss despite intraocular pressure being <21mmHg (8%); or due to poor compliance (4%) (Table-4).
The IOPtiMate system is based on CO2 laser technology that enables the performance of a unique filtration surgery
to treat glaucoma without penetrating the inner part of the eyeball, thus allowing for substantial reductions in post-operative complications and use of eye drops compared with alternatives.
Trabeculectomy is still the most popular surgical technique for glaucoma filtration surgery
and while surgical risks will always exist, in this chapter the authors describe how these can be reduced through pre-, intra-, and post-operative surgical strategies.
The company stated the clear, viscous, low molecular weight dispersive OVD is intended for use as a surgical aid in cataract extraction, intraocular lens (IOL) implantation, corneal transplantation and glaucoma filtration surgery
This drug has been shown to prevent scar tissue formation after glaucoma filtration surgery
, canine subglottic surgery, pediatric choanal atresia repair, rabbit maxillary antrostomy surgery, and after tracheal stenosis repair.
INTRODUCTION: Glaucoma filtration surgery
(GFS) has been shown to be more effective at preventing disease progression than other primary treatment modalities in open angle glaucoma.
2) It also has a fibrotic nature which may result in failure of many interventions such as penetrating keratoplasty and filtration surgery
Conventional glaucoma filtration surgery
have limited role in management of glaucoma after parsplana vitrectomy & silicone oil injection, so adjuvants like Mitomycin-C & 5-Flurouracil are used to prevent fibrosis & failure of trabeculectomy (20).
PRM-151 currently is being tested in a Phase 2a clinical study to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery