filaggrin


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  • noun

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the main protein of the keratohyalin granules

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References in periodicals archive ?
In organotypic culture of a normal human keratinocyte cell line, TCDD has been reported to cause early onset of terminal differentiation, and premature and irregular expression of filaggrin and involucrin, with marked thickening of the keratinized cell layers and hyperkeratosis (Loertscher et al.
A novel filaggrin gene defect has been documented in a single Ethiopian case of AD.
In their new study, the researchers identified a strikingly higher prevalence of inborn mutations in the filaggrin gene among Northern European populations.
Morar N, Cookson WO, Harper JI, Moffatt MF: Filaggrin mutations in children with severe atopic dermatitis.
Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis.
Thirteen contributions from authors directly involved in the original investigations report on such topics as the hygiene hypothesis revisited, loss-of-function mutations within the filaggrin gene, the antimicrobial skin barrier, defective sweating responses, the role of cytokines/chemokines in pathogenesis, biomarkers for itch and disease severity, and practical issues on interpretation of scoring systems, among other topics.
Dr Sara Brown, a fellow at Dundee University, said investigating whether Filaggrin was a cause of peanut allergy was the "logical next step" after its link with eczema and asthma had been established.
British scientists have helped to discover Filaggrin, which can triple the risk of a child developing a peanut allergy.
And since the gene, Filaggrin, had already been linked to eczema and asthma, the Dundee experts decided to see if it was also a factor in nut allergy cases.
Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients' comorbid for atopic disease.
If eczema, hayfever and asthma run in your family, you and your children have a higher risk of developing eczema as it's almost certainly down to a group of genes, one of them being filaggrin We call this having an atopic family, and the risk of passing eczema on to your kids increases even more if both you and your partner have a history of allergies.
Researchers found that mutations in the filaggrin gene in mice leads to allergic inflammation, comparable to that seen in human eczema and related allergic diseases.
Along with the response to RA, there was an associated increase in levels of involucrin and filaggrin at the protein level as demonstrated with immunofluorescent labelling.
Years later, APF and AKA were both found to be directed against filaggrin or its precursor, profilaggrin, and were grouped into a family of antibodies called antifilaggrin autoantibodies (AFA).