Malignant fibrous histiocytoma
(MFH) is an unusual type of renal sarcoma and is believed to arise from primitive mesenchymal cells that demonstrate both histiocytic and fibroblastic differentiation.
Three other diseases in the differential diagnosis also fall into the category of spindle cell sarcomas: malignant fibrous histiocytoma
, fibrosarcoma, and osteosarcoma.
Is cutaneous benign fibrous histiocytoma
(dermatofibroma) a reactive inflammatory process or a neoplasm?
Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma
arising in burn scars.
Surgical Tumor types Thorotrast DU Ta control Benign tumors Benign fibrous histiocytoma
0 1 0 0 Fibroma 0 1 (a) 0 0 Granular cell myoblastoma 1 0 0 0 Malignant tumors Malignant fibrous histiocytoma
13 7 (a) 2 0 Fibrosarcoma 10 2 0 0 Osteosarcoma 1 2 0 0 (a) One rat had two tumors associated with separate implants.
The five biopsies with benign results included two fibroadenomas, one radial scar, one fibrous histiocytoma
, and one area of fibrosis.
Only a few cases of malignant fibrous histiocytoma
of the vocal fold have been previously reported in the literature.
Inflammatory malignant fibrous histiocytoma
of the kidney: An immunohistochemical and ultrastructural study.
Nonossifying fibroma resembles benign fibrous histiocytoma
with a storiform arrangement of the spindle cells and occasional multinucleated giant cells.
This case represents a very rare example of CS/SC of the urinary bladder with a malignant fibrous histiocytoma
component that was characterized by morphologic and immunohistochemical findings, and proves that CS/SC of the urinary bladder is a very aggressive neoplasm.
A CT guided biopsy demonstrated a pleomorphic high grade sarcoma consistent with malignant fibrous histiocytoma
Tumour Type Cycles Best Response Synovial sarcoma 17* SD Ewing's sarcoma 9* SD Malignant Fibrous Histiocytoma
7* SD, tumor resection after cycle 4 Leiomyosarcoma 6 SD Chordoma 5* SD Unspecified Spindle Cell 5* SD * patients still on study
Inflammatory pseudotumor of the lung: progression from organizing pneumonia to fibrous histiocytoma
or plasma cell granuloma in 32 cases.
In view of the age of the patient, the differential diagnosis included metastasis, plasmacytoma, lymphoma, fibrosarcoma, or malignant fibrous histiocytoma
According to data from Memorial Sloan-Kettering Cancer Center, the most common sarcoma found in the extremities is malignant fibrous histiocytoma
, followed by liposarcoma, synovial sarcoma, fibrosarcoma, leiomyosarcoma, and then malignant peripheral nerve tumor (7).