fibrinopeptide


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  • noun

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peptide released from the amino end of fibrinogen by the action of thrombin to form fibrin during clotting of the blood

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References in periodicals archive ?
To help locate the modification site, we incubated purified fibrinogen with thrombin and separated the soluble fibrinopeptides from the resulting fibrin polymer.
Kinetics of fibrinopeptide release by thrombin as a function of Ca[Cl.
Typical (maximum) concentration Peptide or protein mol/L Fibrinopeptide A (in serum) Up to 20 in serum (>40) (a) Fibrinopeptide B (in serum) Up to 20 in serum (>40) (a) Serum amyloid A 0.
Congenital dysfibrinogenemia characterized by defective release of fibrinopeptide A and fibrinogen degradation products.
Its mechanism of action differs from thrombin in that only fibrinopeptide A, and not fibrinopeptide B, is cleaved from fibrinogen.
The results showed that dabigatran almost completely inhibited the production of fibrinopeptide A (FPA), the marker of fibrin formation at the wound site, and that idarucizumab restored FPA production:
54) proposed a proteomic pattern of 22 polypeptides with high diagnostic sensitivity and specificity for urothelial cancer and highlighted fibrinopeptide A as a potential diagnostic biomolecule.
The test evaluates the levels of fibrinopeptide B (FPB), a small peptide that's released when a thrombosis forms and which is removed from the body through urine.
Fibrin detected in plasma of patients with disseminated intravascular coagulation by fibrin specific antibodies consists primarily of high molecular weight factor XIIIa-crosslinked and plasmin-modified complexes partially containing fibrinopeptide A.
In view of the previously observed inverse relationship between heparin concentration and thrombin activity as reflected by fibrinopeptide A concentrations [64], a formal comparison between various POC measurements and anti-Xa heparin concentration measurements was performed [71].
Once detected, the mutation can be characterized by reversed-phase monitoring of fibrinopeptide release [4].
Plasma levels of plasminogen activator inhibitor type-1, [beta]-thromboglobulin, and fibrinopeptide A before, during, and after treatment of acute myocardial infarction with Alteplase.
Thrombin cleaves fibrinogen to form fibrin monomers and release fibrinopeptides A and B.
By cleavage of fibrinopeptides A and B, thrombin produces desAABB-fibrin monomers that polymerize into still-soluble complexes called "thrombus precursor proteins" (TpPs).
9]), anaphylatoxins (C3a, C4a, and C5a), and fibrinopeptides A and B (19).