The diagnosis of CMS can be suspected when there are clinical symptoms of early onset fatigable
muscle weakness, a positive family history, and a decremental response of repetitive nerve stimulation (RNS).
Research has shown that individuals with less fatigable
muscles produce less lactate during exercise, have a higher lactate threshold and are able to perform at higher relative exercise intensities for prolonged periods (Coyle 2005).
There was no fluctuating or fatigable
weakness, creatine kinase, and NCS was normal.
2004) Men are more fatigable
than strength-matched women when performing intermittent submaximal contractions.
In our previous study, we have found that CIH induced the expression of HIF-1a in the genioglossus of mice and altered the physical properties toward a more fatigable
phenotype, inhibiting the overexpression of HIF-1a that might improve the fatigue resistance.
2] during HYB therefore represents the recruitment of highly fatigable
fast-twitch muscle fibers with a low oxidative capacity .
sup] CMSs are clinically heterogeneous and characterized by fatigable
weakness of skeletal muscle that occurs between infancy and adulthood.
Another limitation of FES is muscle fatigue since electrical stimulation may result in a reversed recruitment pattern in which large diameter, fatigable
muscle fibers are recruited first .
SCI leads to several deleterious pathological adaptations similar to disuse atrophy, including increased conversion to fast-twitch fatigable
fibers, decreased lean mass and increased FM, and altered metabolic profile [1-5].
Fatigue is described as an increased weakness with exercise or as the day progresses, as an abnormal constant and persistent sense of tiredness, or as fatigable
weakness exacerbated by activity or heat [7-8].