Other polymorphic sites related to FXIII activity are FXIII 614A/T and FXIII 1694C/T polymorphisms which have been associated with decreased plasma factor XIII
concentrations and lower activity rates, making these FXIII variants candidates for the pathogenesis of thrombotic disorders (8, 10-12).
Using mass spectrometry, the team found that some of the protein sequences in the barnacle glue were quite similar to those in human factor XIII
, which causes fibers to crosslink and form clots.
is the final enzyme in the coagulation cascade and is responsible for catalyzing the intermolecular cross-linking of fibrin polymers, therefore increasing the mechanical rigidity of the fibrin clot (1).
Concentrate (Human) (Corifact; C) is a hematologic agent used for the prophylactic treatment of congenital factor XIII
Triplex amplification of factor XIII
Val34Leu, PAI-1 4G/5G, and MTHFR A1298C was performed with the following conditions: 10 ng of pure genomic DNA, 4.
A total of 132 patient DNA samples were genotyped by both the Tag-It assay and DNA dideoxy sequencing for each of the following six SNPs: factor V Leiden G1691A, factor II G20210A (prothrombin), MTHFR C677T, MTHFR A1298C, factor XIII
va1341eu, and TFPI C536T.
Recurrent episodes of spontaneous subconjunctival hemorrhage in patients with factor XIII
The factor XIII
V34L polymorphism accelerates thrombin activation of factor XIII
and affects cross-linked fibrin structure.
Blood coagulation factor XIII
(FXIII)  is a pro-transglutaminase of tetrameric structure ([A.
Present-day applications of these methods in the clinical diagnostic laboratory include direct DNA tests to detect such common clinical syndromes as hemochromatosis (caused by FIFE gene alterations) (9-11) and thrombotic predisposition [caused by mutations in factor V (R506Q and A4070G) (7,12), factor II (prothrombin G20210A) (7), methylenetetrahydrofolate reductase (MTHFR C677T) (7), factor XIII
(Va134Leu) (13), plasminogen activator inhibitor-1 (4G/5G) (14), and angiotensin 1-converting enzyme (insertion/ deletion) (15)].
BAC contains naturally occurring clotting-related proteins, including fibrinogen, Factor XIII
, Factor VIII, fibronectin and van Willebrand factor antigen.
About recombinant coagulation factor XIII
This reported amount does not reflect approximately $96 million of net proceeds receivable in the fourth quarter from two transactions completed in October: a strategic alliance with Serono and a license of recombinant Factor XIII
to Novo Nordisk.
Coagulation factor concentrates are subsegmented into factor VIII, factor IX, factor XIII
, prothrombin coagulation concentrates, Von Willebrand factors, and fibrinogen concentrates.
recombinant Factor XIII
portfolio, including all related intellectual